IGKV1D-12

Across TCGA pan-cancer cohorts, IGKV1D-12 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGKV1D-12 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1D-12 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1D-12 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV1D-12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.784	0.636	<.001	144	view →
SKCM	OS	Median	All	0.403	0.275	<.001	89	view →
BRCA	DFS	Tertile	All	0.968	0.917	<.001	77	view →
COAD	DFS	Median	All	0.628	0.436	.001	68	view →
CESC	OS	Median	All	0.890	0.709	<.001	64	view →
LUAD	DFS	Tertile	II,III,IV	0.725	0.453	.001	57	view →
GBM	OS	Tertile	All	0.250	0.457	.006	36	view →
KIRC	DFS	Tertile	All	0.681	0.858	.003	16	view →
TGCT	DFS	Quartile	All	0.897	0.597	.013	14	view →
DLBC	DFS	Median	III,IV	0.984	0.294	.003	13	view →
UCEC	OS	Tertile	III,IV	0.711	0.450	.020	12	view →
READ	OS	Tertile	III,IV	0.776	1.000	.016	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGKV1D-12–HNSC (DFS)

Open the HNSC breakdown →