IGKV1D-12

Across TCGA patient cohorts, IGKV1D-12 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV1D-12-associated genes across cancer lineages are MIR605, TRAJ40, and RNA5SP23. Each is linked with IGKV1D-12 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-12-to-partner and partner-to-IGKV1D-12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR605 grouped by IGKV1D-12-low versus IGKV1D-12-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-12→partner) and Y-score (partner→IGKV1D-12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR605 →	+0.559	+5.191	<.001	.003	3	1
LUSC	TRAJ40 →	+0.585	+4.503	.002	.005	3	1
LUSC	RNA5SP23 →	+0.300	+5.438	.001	.002	3	1
LUSC	RNU4-6P →	+0.287	+5.733	<.001	.001	3	1
LUSC	RNU7-50P →	+0.793	+4.993	<.001	.002	3	1
LUSC	RNU7-127P →	+0.394	+4.792	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MIR605 by IGKV1D-12 expression — LUSC

Explore this box plot interactively →