IGKV1-9

Across TCGA patient cohorts, IGKV1-9 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKV1-9-associated genes across cancer lineages are RNU7-129P, TMEM239, and RNA5SP378. Each is linked with IGKV1-9 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-9-to-partner and partner-to-IGKV1-9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-129P grouped by IGKV1-9-low versus IGKV1-9-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-9→partner) and Y-score (partner→IGKV1-9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU7-129P →	+0.425	+4.706	<.001	.007	3	2
SKCM	TMEM239 →	+0.025	+3.798	<.001	.002	3	1
SKCM	RNA5SP378 →	+0.321	+3.669	<.001	.006	3	1
SKCM	RNA5SP245 →	+0.413	+3.911	.006	.004	3	1
SKCM	RN7SKP71 →	+0.165	+3.533	<.001	.007	3	1
SKCM	RNU6-328P →	+0.202	+4.199	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

RNU7-129P by IGKV1-9 expression — LUSC

Explore this box plot interactively →