IGKV1-5

Across TCGA patient cohorts, IGKV1-5 mutation is significantly associated with the RNA expression of many other genes, with 270 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGKV1-5-associated genes across cancer lineages are TRAJ22, MIR561, and USP9YP2. Each is linked with IGKV1-5 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGKV1-5-to-partner and partner-to-IGKV1-5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ22 grouped by IGKV1-5-low versus IGKV1-5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-5→partner) and Y-score (partner→IGKV1-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ22 →	+1.367	+4.181	<.001	.009	3	3
SKCM	MIR561 →	+0.683	+3.032	<.001	.009	3	2
LUAD	USP9YP2 →	+0.013	+4.014	<.001	.007	3	2
UCEC	TRAJ43 →	+1.075	+4.211	<.001	<.001	3	2
SKCM	MIR5680 →	+0.207	+4.147	<.001	.008	3	2
BRCA	MIR6715A →	+0.276	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 270 associations by consensus.

TRAJ22 by IGKV1-5 expression — COAD

Explore this box plot interactively →