IGKV1-5

Across TCGA patient cohorts, IGKV1-5 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGKV1-5-associated genes across cancer lineages are CD49b, B-Raf, and Cyclin-E1. Each is linked with IGKV1-5 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-5-to-partner and partner-to-IGKV1-5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by IGKV1-5-low versus IGKV1-5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-5→partner) and Y-score (partner→IGKV1-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CD49b →	-0.353	-2.321	.007	.035	2	2
LUAD	B-Raf →	+0.483	+2.338	.005	.019	2	1
LUAD	Cyclin-E1 →	+0.323	+3.459	.008	.005	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CD49b by IGKV1-5 expression — LUAD

Explore this box plot interactively →