IGKV1-39

Across TCGA patient cohorts, IGKV1-39 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV1-39-associated genes across cancer lineages are TMEM174, OR4M1, and OR6C75. Each is linked with IGKV1-39 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-39-to-partner and partner-to-IGKV1-39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM174 grouped by IGKV1-39-low versus IGKV1-39-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-39→partner) and Y-score (partner→IGKV1-39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TMEM174 →	+0.039	+4.979	.005	.009	3	1
SKCM	OR4M1 →	+0.056	+5.513	<.001	.004	3	1
SKCM	OR6C75 →	+0.066	+5.970	<.001	.002	3	1
SKCM	OR51I2 →	+0.069	+5.867	<.001	.003	3	1
SKCM	RNU6-79P →	+0.334	+5.097	<.001	.008	3	1
SKCM	RNU6-1169P →	+0.351	+5.362	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

TMEM174 by IGKV1-39 expression — SKCM

Explore this box plot interactively →