IGKV1-39

Across TCGA pan-cancer cohorts, IGKV1-39 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGKV1-39 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1-39 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1-39 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGKV1-39 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.772	0.620	<.001	144	view →
SKCM	OS	Tertile	All	0.462	0.270	<.001	109	view →
BRCA	DFS	Quartile	All	0.578	0.457	<.001	58	view →
CESC	OS	Median	II,III,IV	0.864	0.637	.001	32	view →
OV	DFS	Quartile	II,III,IV	0.425	0.319	.007	30	view →
MESO	OS	Median	All	0.698	0.320	.015	27	view →
CHOL	DFS	Median	All	0.666	0.182	.001	21	view →
BLCA	OS	Quartile	IV	0.629	0.246	.017	18	view →
KICH	DFS	Tertile	III,IV	0.025	0.773	<.001	18	view →
KIRC	DFS	Median	All	0.771	0.833	.022	15	view →
COAD	OS	Tertile	IV	0.759	0.252	.003	15	view →
STAD	OS	Median	IV	0.642	0.194	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGKV1-39–HNSC (DFS)

Open the HNSC breakdown →