IGKV1-37

Across TCGA patient cohorts, IGKV1-37 RNA expression is significantly associated with the protein abundance of many other proteins, with 6,052 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKV1-37-associated proteins across cancer lineages are MZB1, TXNDC5, and PLCG2. Each is linked with IGKV1-37 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGKV1-37-to-partner and partner-to-IGKV1-37 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGKV1-37 versus MZB1 in BRCA, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-37→partner) and Y-score (partner→IGKV1-37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MZB1 →	+0.983	+0.423	<.001	<.001	3	6
LSCC	TXNDC5 →	+0.587	+0.537	<.001	<.001	3	5
LSCC	PLCG2 →	+0.536	+0.579	<.001	<.001	3	5
LSCC	RASAL3 →	+0.377	+0.440	<.001	<.001	3	5
LSCC	MANF →	+0.574	+0.529	<.001	<.001	3	5
LSCC	SEC11C →	+1.043	+0.508	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,052 associations by consensus.

IGKV1-37 vs MZB1 — BRCA

Explore this scatter interactively →