IGKV1-37

Across TCGA pan-cancer cohorts, IGKV1-37 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated IGKV1-37 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1-37 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1-37 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where IGKV1-37 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.413	0.278	<.001	132	view →
SKCM	OS	Tertile	All	0.467	0.297	<.001	81	view →
UVM	OS	Tertile	III,IV	0.104	0.813	.001	45	view →
CESC	OS	Tertile	IV	0.897	0.371	.010	44	view →
ESCA	DFS	Quartile	All	0.648	0.439	.012	30	view →
KICH	DFS	Tertile	All	0.521	0.969	.037	27	view →
CHOL	DFS	Tertile	All	0.873	0.280	.007	18	view →
DLBC	OS	Tertile	II,III,IV	0.563	1.000	.008	18	view →
BRCA	DFS	Tertile	III,IV	0.644	0.414	.016	13	view →
KIRP	DFS	Tertile	All	0.570	0.819	.036	12	view →
LUAD	OS	Quartile	II,III,IV	0.729	0.462	.007	11	view →
LUSC	DFS	Median	III,IV	0.453	0.203	.013	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

IGKV1-37–HNSC (DFS)

Open the HNSC breakdown →