IGKV1-37

Across TCGA pan-cancer cohorts, IGKV1-37 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGKV1-37’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1-37 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1-37 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, LUAD, and STAD are the cancer types where IGKV1-37 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1-37 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.678	<.001	11	view →
LUAD	Female	All	+0.486	<.001	7	view →
STAD	Male	IV	−2.320	.009	5	view →
KIRC	Male	III,IV	+0.122	.009	5	view →
ESCA	All	II,III,IV	+1.035	.021	3	view →
LUSC	All	All	+0.226	.018	2	view →
BRCA	All	III,IV	−0.170	.030	2	view →
READ	Female	All	−0.444	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGKV1-37–COAD

Open the COAD breakdown →