IGKV1-37

Across TCGA patient cohorts, IGKV1-37 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV1-37-associated genes across cancer lineages are MIR412, RNU6-591P, and MIR4476. Each is linked with IGKV1-37 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-37-to-partner and partner-to-IGKV1-37 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR412 grouped by IGKV1-37-low versus IGKV1-37-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-37→partner) and Y-score (partner→IGKV1-37) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR412 →	+0.621	+8.066	<.001	.007	3	1
UCEC	RNU6-591P →	+0.652	+8.066	<.001	.007	3	1
UCEC	MIR4476 →	+0.736	+8.066	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MIR412 by IGKV1-37 expression — UCEC

Explore this box plot interactively →