IGKV1-33

Across TCGA patient cohorts, IGKV1-33 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV1-33-associated genes across cancer lineages are MIR3130-2, MIR3912, and MIR4254. Each is linked with IGKV1-33 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-33-to-partner and partner-to-IGKV1-33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3130-2 grouped by IGKV1-33-low versus IGKV1-33-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-33→partner) and Y-score (partner→IGKV1-33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR3130-2 →	+0.817	+4.884	<.001	<.001	3	1
UCEC	MIR3912 →	+0.627	+4.223	<.001	.003	3	1
UCEC	MIR4254 →	+0.530	+4.442	<.001	.007	3	1
UCEC	MIR5692C2 →	+0.691	+4.109	.002	.004	3	1
UCEC	CTAGE6 →	+0.069	+3.993	.006	.006	3	1
UCEC	RNU6-92P →	+0.363	+5.292	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MIR3130-2 by IGKV1-33 expression — UCEC

Explore this box plot interactively →