IGKV1-33

Across TCGA pan-cancer cohorts, IGKV1-33 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGKV1-33 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1-33 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1-33 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where IGKV1-33 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.758	0.633	<.001	144	view →
SKCM	OS	Median	All	0.417	0.268	<.001	135	view →
UVM	OS	Tertile	All	0.461	0.880	<.001	108	view →
KIRC	DFS	Tertile	All	0.459	0.717	.001	34	view →
SARC	DFS	Tertile	All	0.752	0.469	.002	33	view →
BRCA	DFS	Quartile	All	0.607	0.481	.005	24	view →
KIRP	DFS	Quartile	All	0.496	0.841	.003	21	view →
CESC	OS	Tertile	All	0.863	0.728	.011	14	view →
READ	OS	Tertile	II,III,IV	0.949	0.334	.015	13	view →
LGG	OS	Tertile	All	0.192	0.526	.002	12	view →
THYM	DFS	Tertile	III,IV	0.545	0.913	.011	10	view →
OV	OS	Median	II,III,IV	0.378	0.281	.024	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGKV1-33–HNSC (DFS)

Open the HNSC breakdown →