IGKV1-33

Across TCGA pan-cancer cohorts, IGKV1-33 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of IGKV1-33’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGKV1-33 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGKV1-33 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

LUAD, COAD, and BRCA are the cancer types where IGKV1-33 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1-33 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	+1.974	<.001	9	view →
COAD	Female	All	−2.000	<.001	8	view →
BRCA	Female	II,III,IV	−0.496	.009	6	view →
KIRC	All	All	+0.384	.001	4	view →
ESCA	All	All	+1.843	.019	2	view →
READ	All	All	−1.621	.001	2	view →
STAD	All	IV	−4.710	.021	1	view →
LUSC	All	All	+0.706	.048	1	view →
BLCA	Male	III,IV	+0.628	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

IGKV1-33–LUAD

Open the LUAD breakdown →