IGKV1-17

Across TCGA patient cohorts, IGKV1-17 mutation is significantly associated with the RNA expression of many other genes, with 942 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV1-17-associated genes across cancer lineages are KCNJ2, ATP5MC1, and TOLLIP. Each is linked with IGKV1-17 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-17-to-partner and partner-to-IGKV1-17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNJ2 grouped by IGKV1-17-low versus IGKV1-17-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-17→partner) and Y-score (partner→IGKV1-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	KCNJ2 →	-0.552	-3.875	.003	<.001	3	2
SKCM	ATP5MC1 →	+0.458	+2.185	.001	.009	3	2
SKCM	TOLLIP →	+0.510	+2.813	.002	.001	3	2
SKCM	POMGNT1 →	+0.431	+3.468	.007	.002	3	2
UCEC	RN7SL260P →	+0.130	+2.547	.007	.009	3	2
UCEC	CRYBB2P1 →	+0.607	+3.606	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 942 associations by consensus.

KCNJ2 by IGKV1-17 expression — SKCM

Explore this box plot interactively →