IGKV1-17

Across TCGA patient cohorts, IGKV1-17 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKV1-17-associated genes across cancer lineages are FoxM1, STAT3_pY705, and Tuberin. Each is linked with IGKV1-17 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-17-to-partner and partner-to-IGKV1-17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by IGKV1-17-low versus IGKV1-17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-17→partner) and Y-score (partner→IGKV1-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.312	+3.169	.027	.020	3	1
UCEC	STAT3_pY705 →	-0.658	-3.169	<.001	.020	3	1
UCEC	Tuberin →	+0.392	+3.169	.008	.020	3	1
UCEC	VHL →	-1.124	-3.000	.002	.036	3	1
UCEC	ATM →	-0.601	-3.169	.015	.020	3	1
UCEC	eIF4E →	+0.256	+3.169	.027	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FoxM1 by IGKV1-17 expression — UCEC

Explore this box plot interactively →