IGKV1-16

Across TCGA patient cohorts, IGKV1-16 mutation is significantly associated with the RNA expression of many other genes, with 155 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV1-16-associated genes across cancer lineages are RNU6-806P, RNU6-39P, and RNU6-258P. Each is linked with IGKV1-16 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-16-to-partner and partner-to-IGKV1-16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-806P grouped by IGKV1-16-low versus IGKV1-16-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-16→partner) and Y-score (partner→IGKV1-16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-806P →	+0.470	+4.496	<.001	.007	3	2
LUSC	RNU6-39P →	+0.574	+5.099	<.001	<.001	3	2
LUSC	RNU6-258P →	+0.242	+4.993	<.001	.003	3	2
LUSC	NDUFB2P1 →	+0.176	+4.678	<.001	.001	3	2
LUSC	MIR3925 →	+0.458	+5.666	<.001	<.001	3	2
LUAD	KCNK18 →	+0.069	+4.216	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 155 associations by consensus.

RNU6-806P by IGKV1-16 expression — LUSC

Explore this box plot interactively →