IGKV1-16

Across TCGA pan-cancer cohorts, IGKV1-16 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated IGKV1-16 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1-16 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1-16 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where IGKV1-16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.757	0.635	<.001	143	view →
SKCM	OS	Median	All	0.399	0.279	<.001	116	view →
UVM	DFS	Median	II,III,IV	0.379	0.677	<.001	43	view →
SARC	OS	Median	All	0.602	0.407	<.001	40	view →
BRCA	DFS	Tertile	All	0.972	0.919	<.001	39	view →
ACC	DFS	Tertile	All	0.808	0.471	.002	35	view →
COAD	DFS	Tertile	III,IV	0.783	0.391	.007	34	view →
UCS	DFS	Median	IV	0.952	0.367	.001	32	view →
PAAD	OS	Tertile	II,III,IV	0.681	0.482	.007	25	view →
KIRC	DFS	Quartile	All	0.449	0.686	.006	20	view →
STAD	OS	Median	IV	0.642	0.194	.003	18	view →
MESO	OS	Tertile	All	0.684	0.226	.019	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

IGKV1-16–HNSC (DFS)

Open the HNSC breakdown →