IGKV1-16

Across TCGA pan-cancer cohorts, IGKV1-16 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IGKV1-16’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGKV1-16 RNA is repressed in tumor relative to normal tissue. In most cancer types IGKV1-16 is over-expressed in tumor, although a few such as COAD and LIHC show the opposite, repressed pattern.

COAD, LIHC, and LUAD are the cancer types where IGKV1-16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1-16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−3.172	<.001	9	view →
LIHC	Male	All	−2.296	<.001	6	view →
LUAD	Female	All	+2.250	<.001	6	view →
KIRC	Male	All	+1.873	<.001	5	view →
BRCA	Female	II,III,IV	−1.138	<.001	4	view →
ESCA	All	II,III,IV	+3.840	.006	2	view →
UCEC	All	IV	+2.780	.008	2	view →
READ	Female	All	−2.757	.028	2	view →
CHOL	All	II,III,IV	−2.090	.034	2	view →
KICH	All	II,III,IV	−1.346	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IGKV1-16–COAD

Open the COAD breakdown →