IGKV1-16

Across TCGA patient cohorts, IGKV1-16 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV1-16-associated genes across cancer lineages are Endothelial cells and NKT. Each is linked with IGKV1-16 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-16-to-partner and partner-to-IGKV1-16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial cells grouped by IGKV1-16-low versus IGKV1-16-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-16→partner) and Y-score (partner→IGKV1-16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Endothelial cells →	-0.039	-2.933	.018	.036	3	1
SKCM	NKT →	+0.102	+2.188	.038	.034	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Endothelial cells by IGKV1-16 expression — SKCM

Explore this box plot interactively →