IGKV1-13

Across TCGA patient cohorts, IGKV1-13 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV1-13-associated genes across cancer lineages are MIR204, RNA5SP401, and MIR4330. Each is linked with IGKV1-13 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1-13-to-partner and partner-to-IGKV1-13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR204 grouped by IGKV1-13-low versus IGKV1-13-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1-13→partner) and Y-score (partner→IGKV1-13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR204 →	+0.426	+5.548	<.001	.004	3	2
LUSC	RNA5SP401 →	+0.484	+5.211	<.001	.007	3	2
HNSC	MIR4330 →	+0.298	+7.954	<.001	.008	3	2
COAD	RNU6-709P →	+0.992	+7.142	<.001	<.001	3	2
BLCA	RNU6-799P →	+0.350	+4.973	.001	.009	3	1
LUSC	RNU6-1290P →	+0.504	+5.625	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

MIR204 by IGKV1-13 expression — LUSC

Explore this box plot interactively →