IGKV1-13

Across TCGA pan-cancer cohorts, IGKV1-13 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGKV1-13 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1-13 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV1-13 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where IGKV1-13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.761	0.611	<.001	138	view →
BRCA	OS	Median	All	0.974	0.950	.001	55	view →
SKCM	OS	Tertile	All	0.475	0.285	<.001	54	view →
KIRP	DFS	Quartile	All	0.742	0.896	<.001	49	view →
ESCA	DFS	Median	III,IV	0.426	0.230	.010	26	view →
LUAD	DFS	Median	II,III,IV	0.678	0.471	.009	22	view →
PAAD	OS	Tertile	II,III,IV	0.657	0.425	.001	21	view →
UVM	OS	Tertile	All	0.254	0.617	.039	18	view →
GBM	OS	Tertile	All	0.295	0.429	.010	18	view →
MESO	OS	Median	All	0.688	0.330	.025	15	view →
PCPG	DFS	Tertile	All	0.869	0.930	.032	15	view →
CHOL	DFS	Median	All	0.723	0.233	.035	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGKV1-13–HNSC (OS)

Open the HNSC breakdown →