IGKV1-13

Across TCGA pan-cancer cohorts, IGKV1-13 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGKV1-13’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGKV1-13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGKV1-13 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LUAD, KIRC, and COAD are the cancer types where IGKV1-13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGKV1-13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+1.128	<.001	7	view →
KIRC	All	All	+0.326	.001	4	view →
COAD	Female	III,IV	−1.180	.004	2	view →
HNSC	All	III,IV	+0.662	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IGKV1-13–LUAD

Open the LUAD breakdown →