IGHVII-65-1

Across TCGA patient cohorts, IGHVII-65-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,963 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGHVII-65-1-associated GO terms across cancer lineages are B cell mediated immunity, Immunoglobulin production, and B cell receptor signaling pathway. Each is linked with IGHVII-65-1 in more than 4 cancer types. Because this analysis shows association rather than direction, both IGHVII-65-1-to-partner and partner-to-IGHVII-65-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell mediated immunity grouped by IGHVII-65-1-low versus IGHVII-65-1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVII-65-1→partner) and Y-score (partner→IGHVII-65-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	B cell mediated immunity →	+0.134	+0.083	<.001	<.001	3	5
ESCA	Immunoglobulin production →	+0.110	+0.091	<.001	<.001	3	5
STAD	B cell receptor signaling pathway →	+0.126	+0.045	<.001	.003	3	5
STAD	T cell activation involved in immune response →	+0.087	+0.079	<.001	.004	3	4
STAD	Positive regulation of leukocyte chemotaxis →	+0.090	+0.042	<.001	.005	3	4
STAD	Regulation of endocytosis →	+0.066	+0.087	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,963 associations by consensus.

B cell mediated immunity by IGHVII-65-1 expression — ESCA

Explore this box plot interactively →