IGHVII-65-1

Across TCGA pan-cancer cohorts, IGHVII-65-1 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated IGHVII-65-1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher IGHVII-65-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHVII-65-1 expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

KIRC, STAD, and OV are the cancer types where IGHVII-65-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.510	0.798	.019	90	view →
STAD	DFS	Tertile	All	0.401	0.644	<.001	84	view →
OV	OS	Tertile	IV	0.028	0.759	.002	36	view →
COAD	OS	Tertile	All	0.168	0.806	.002	36	view →
LUAD	OS	Tertile	II,III,IV	0.260	0.684	.002	27	view →
PCPG	DFS	Tertile	All	0.097	0.817	<.001	18	view →
ESCA	OS	Tertile	III,IV	0.755	0.366	.037	12	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGHVII-65-1–KIRC (DFS)

Open the KIRC breakdown →