IGHVII-60-1

Across TCGA patient cohorts, IGHVII-60-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,587 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHVII-60-1-associated GO terms across cancer lineages are B cell receptor signaling pathway, Positive regulation of alpha-beta T cell proliferation, and Positive T cell selection. Each is linked with IGHVII-60-1 in more than 22 cancer types. Because this analysis shows association rather than direction, both IGHVII-60-1-to-partner and partner-to-IGHVII-60-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B cell receptor signaling pathway grouped by IGHVII-60-1-low versus IGHVII-60-1-high in PAAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVII-60-1→partner) and Y-score (partner→IGHVII-60-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	B cell receptor signaling pathway →	+0.096	+0.170	<.001	<.001	3	23
SKCM	Positive regulation of alpha-beta T cell proliferation →	+0.089	+0.183	<.001	<.001	3	22
SARC	Positive T cell selection →	+0.088	+0.093	<.001	.002	2	22
SKCM	Positive regulation of B cell differentiation →	+0.100	+0.186	<.001	<.001	3	21
SARC	Alpha-beta T cell activation →	+0.067	+0.066	<.001	.004	3	21
SARC	Antigen receptor-mediated signaling pathway →	+0.076	+0.070	<.001	.002	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,587 associations by consensus.

B cell receptor signaling pathway by IGHVII-60-1 expression — PAAD

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