IGHVII-60-1

Across TCGA pan-cancer cohorts, IGHVII-60-1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated IGHVII-60-1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHVII-60-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHVII-60-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and STAD are the cancer types where IGHVII-60-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.783	0.668	.001	99	view →
LUAD	OS	Tertile	All	0.750	0.640	.002	69	view →
STAD	DFS	Tertile	II,III,IV	0.234	0.432	.010	27	view →
LIHC	DFS	Tertile	III,IV	0.120	0.355	.003	27	view →
LUSC	OS	Quartile	II,III,IV	0.621	0.795	.002	24	view →
KIRP	DFS	Tertile	III,IV	0.040	0.691	<.001	21	view →
CESC	OS	Tertile	All	0.797	0.531	.016	18	view →
TGCT	DFS	Tertile	All	0.890	0.603	.017	16	view →
SKCM	DFS	Tertile	All	0.703	0.599	.016	12	view →
DLBC	OS	Tertile	IV	0.610	1.000	.021	12	view →
ESCA	DFS	Tertile	IV	0.221	0.539	.046	12	view →
THYM	DFS	Tertile	III,IV	0.214	1.000	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

IGHVII-60-1–HNSC (DFS)

Open the HNSC breakdown →