IGHVII-60-1

Across TCGA pan-cancer cohorts, IGHVII-60-1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of IGHVII-60-1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHVII-60-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHVII-60-1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LUAD, COAD, and KIRC are the cancer types where IGHVII-60-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVII-60-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.430	<.001	5	view →
COAD	Female	All	−0.259	<.001	5	view →
KIRC	Male	All	+0.031	.019	3	view →
LUSC	Male	All	+0.223	.004	2	view →
ESCA	Female	All	+0.190	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

IGHVII-60-1–LUAD

Open the LUAD breakdown →