IGHVII-46-1

Across TCGA patient cohorts, IGHVII-46-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,561 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGHVII-46-1-associated GO terms across cancer lineages are Regulation of transcription elongation by RNA polymerase II, DNA-templated transcription elongation, and Mitochondrial genome maintenance. Each is linked with IGHVII-46-1 in more than 12 cancer types. Because this analysis shows association rather than direction, both IGHVII-46-1-to-partner and partner-to-IGHVII-46-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription elongation by RNA polymerase II grouped by IGHVII-46-1-low versus IGHVII-46-1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVII-46-1→partner) and Y-score (partner→IGHVII-46-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of transcription elongation by RNA polymerase II →	+0.081	+0.472	<.001	<.001	3	13
STAD	DNA-templated transcription elongation →	+0.086	+0.431	<.001	<.001	3	12
STAD	Mitochondrial genome maintenance →	+0.072	+0.248	<.001	<.001	3	11
STAD	Somatic diversification of immune receptors →	+0.069	+0.383	<.001	<.001	3	11
STAD	Regulation of DNA-templated transcription elongation →	+0.083	+0.428	<.001	<.001	3	11
STAD	Positive regulation of isotype switching →	+0.054	+0.423	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,561 associations by consensus.

Regulation of transcription elongation by RNA polymerase II by IGHVII-46-1 expression — STAD

Explore this box plot interactively →