IGHVII-46-1

Across TCGA pan-cancer cohorts, IGHVII-46-1 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated IGHVII-46-1 data layer.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher IGHVII-46-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHVII-46-1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCS show a favorable association.

TGCT, LIHC, and LUAD are the cancer types where IGHVII-46-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	DFS	Tertile	II,III,IV	0.622	0.978	.016	54	view →
LIHC	OS	Tertile	II,III,IV	0.341	0.715	<.001	48	view →
LUAD	DFS	Tertile	II,III,IV	0.899	0.393	.019	33	view →
LGG	DFS	Tertile	All	0.694	0.832	.010	30	view →
ESCA	DFS	Tertile	All	0.135	0.522	<.001	30	view →
STAD	DFS	Quartile	IV	0.224	0.546	.010	30	view →
THCA	OS	Tertile	II,III,IV	0.178	0.904	<.001	27	view →
BRCA	OS	Tertile	III,IV	0.728	0.912	.004	24	view →
OV	OS	Tertile	III,IV	0.197	0.321	.038	24	view →
UCS	DFS	Tertile	III,IV	1.000	0.222	.046	12	view →
THYM	DFS	Tertile	II,III,IV	0.371	0.857	.005	10	view →
KIRC	DFS	Tertile	All	1.000	0.603	.048	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

IGHVII-46-1–TGCT (DFS)

Open the TGCT breakdown →