IGHVII-46-1

Across TCGA pan-cancer cohorts, IGHVII-46-1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of IGHVII-46-1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where IGHVII-46-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IGHVII-46-1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LUAD and COAD are the cancer types where IGHVII-46-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHVII-46-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.315	.039	1	view →
COAD	All	All	−0.157	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

IGHVII-46-1–LUAD

Open the LUAD breakdown →