IGHVII-28-1

Across TCGA patient cohorts, IGHVII-28-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,784 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGHVII-28-1-associated GO terms across cancer lineages are T cell selection, Positive thymic T cell selection, and Regulation of B cell activation. Each is linked with IGHVII-28-1 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHVII-28-1-to-partner and partner-to-IGHVII-28-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, T cell selection grouped by IGHVII-28-1-low versus IGHVII-28-1-high in SARC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHVII-28-1→partner) and Y-score (partner→IGHVII-28-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	T cell selection →	+0.085	+0.107	<.001	.004	3	10
THYM	Positive thymic T cell selection →	+0.164	+2.253	<.001	<.001	3	10
STAD	Regulation of B cell activation →	+0.055	+0.225	<.001	.002	3	9
SARC	Regulation of leukocyte mediated immunity →	+0.044	+0.186	<.001	.003	3	9
THYM	Thymic T cell selection →	+0.112	+1.794	<.001	<.001	3	9
KIRP	Immunoglobulin production →	+0.091	+0.115	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,784 associations by consensus.

T cell selection by IGHVII-28-1 expression — SARC

Explore this box plot interactively →