IGHVII-28-1

Across TCGA pan-cancer cohorts, IGHVII-28-1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated IGHVII-28-1 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher IGHVII-28-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHVII-28-1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

THCA, LUAD, and READ are the cancer types where IGHVII-28-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	All	0.650	0.902	<.001	135	view →
LUAD	DFS	Tertile	II,III,IV	0.835	0.526	.012	57	view →
READ	OS	Tertile	All	0.364	0.927	<.001	54	view →
KIRP	DFS	Tertile	All	0.647	0.893	.012	36	view →
KIRC	DFS	Tertile	IV	0.127	0.619	.008	36	view →
THYM	DFS	Tertile	III,IV	0.362	0.894	.004	18	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
ACC	OS	Tertile	All	0.118	0.624	.038	18	view →
ESCA	DFS	Tertile	III,IV	0.103	0.442	.021	18	view →
PCPG	DFS	Tertile	All	0.229	0.821	.031	18	view →
LAML	DFS	Tertile	All	0.154	0.578	.040	18	view →
LGG	DFS	Tertile	All	0.110	0.826	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

IGHVII-28-1–THCA (DFS)

Open the THCA breakdown →