IGHV8-51-1

Across TCGA patient cohorts, IGHV8-51-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,798 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGHV8-51-1-associated GO terms across cancer lineages are Immunoglobulin production, B cell mediated immunity, and Antimicrobial humoral response. Each is linked with IGHV8-51-1 in more than 24 cancer types. Because this analysis shows association rather than direction, both IGHV8-51-1-to-partner and partner-to-IGHV8-51-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Immunoglobulin production grouped by IGHV8-51-1-low versus IGHV8-51-1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV8-51-1→partner) and Y-score (partner→IGHV8-51-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Immunoglobulin production →	+0.082	+0.488	<.001	<.001	3	25
THCA	B cell mediated immunity →	+0.106	+0.491	<.001	<.001	3	24
THCA	Antimicrobial humoral response →	+0.115	+0.455	<.001	<.001	3	24
THCA	Antibacterial humoral response →	+0.174	+0.464	<.001	<.001	3	24
SKCM	Lymphocyte activation involved in immune response →	+0.039	+0.270	<.001	<.001	3	24
SKCM	B cell differentiation →	+0.056	+0.273	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,798 associations by consensus.

Immunoglobulin production by IGHV8-51-1 expression — ESCA

Explore this box plot interactively →