IGHV7-56

Across TCGA patient cohorts, IGHV7-56 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV7-56-associated genes across cancer lineages are DEFB103A, RNU6-1047P, and OFD1P9Y. Each is linked with IGHV7-56 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV7-56-to-partner and partner-to-IGHV7-56 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB103A grouped by IGHV7-56-low versus IGHV7-56-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV7-56→partner) and Y-score (partner→IGHV7-56) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DEFB103A →	+0.109	+7.930	<.001	.008	3	1
LUAD	RNU6-1047P →	+0.412	+7.930	<.001	.008	3	1
LUAD	OFD1P9Y →	+0.039	+7.930	<.001	.008	3	1
SKCM	OR51G1 →	+0.044	+7.816	<.001	.008	3	1
SKCM	OFD1P11Y →	+0.039	+7.816	<.001	.008	3	1
SKCM	MIR3152 →	+0.478	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

DEFB103A by IGHV7-56 expression — LUAD

Explore this box plot interactively →