IGHV7-56

Across TCGA pan-cancer cohorts, IGHV7-56 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGHV7-56 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV7-56 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV7-56 expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

HNSC, ACC, and DLBC are the cancer types where IGHV7-56 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.777	0.642	<.001	144	view →
ACC	DFS	Tertile	III,IV	0.010	0.458	<.001	63	view →
DLBC	DFS	Tertile	II,III,IV	0.070	0.887	<.001	58	view →
MESO	OS	Median	II,III,IV	0.731	0.315	.004	30	view →
BRCA	OS	Tertile	All	0.979	0.949	.010	21	view →
KIRP	DFS	Quartile	All	0.535	0.860	.005	19	view →
GBM	OS	Tertile	All	0.231	0.424	.014	18	view →
KIRC	DFS	Quartile	All	0.650	0.833	.002	16	view →
LUAD	OS	Quartile	II,III,IV	0.815	0.530	.010	12	view →
TGCT	DFS	Tertile	All	0.922	0.748	.019	10	view →
READ	DFS	Median	IV	0.772	0.379	.006	9	view →
SKCM	DFS	Quartile	All	0.778	0.602	.013	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGHV7-56–HNSC (DFS)

Open the HNSC breakdown →