IGHV7-56

Across TCGA pan-cancer cohorts, IGHV7-56 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGHV7-56’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV7-56 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV7-56 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGHV7-56 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV7-56 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−1.194	<.001	8	view →
LUAD	Female	All	+1.048	<.001	5	view →
BRCA	Female	II,III,IV	−0.360	.002	4	view →
KIRC	All	All	+0.292	<.001	4	view →
STAD	All	IV	−3.630	.006	3	view →
READ	All	All	−1.012	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGHV7-56–COAD

Open the COAD breakdown →