IGHV7-40

Across TCGA patient cohorts, IGHV7-40 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,621 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGHV7-40-associated GO terms across cancer lineages are Antigen receptor-mediated signaling pathway, B cell receptor signaling pathway, and Positive regulation of alpha-beta T cell activation. Each is linked with IGHV7-40 in more than 22 cancer types. Because this analysis shows association rather than direction, both IGHV7-40-to-partner and partner-to-IGHV7-40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen receptor-mediated signaling pathway grouped by IGHV7-40-low versus IGHV7-40-high in THCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV7-40→partner) and Y-score (partner→IGHV7-40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Antigen receptor-mediated signaling pathway →	+0.055	+0.261	<.001	<.001	3	23
PAAD	B cell receptor signaling pathway →	+0.074	+0.208	<.001	<.001	3	23
THCA	Positive regulation of alpha-beta T cell activation →	+0.054	+0.255	<.001	<.001	3	23
THCA	B cell mediated immunity →	+0.103	+0.248	<.001	<.001	3	23
THCA	Antibacterial humoral response →	+0.154	+0.224	<.001	<.001	3	22
THCA	Immunoglobulin production →	+0.073	+0.239	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,621 associations by consensus.

Antigen receptor-mediated signaling pathway by IGHV7-40 expression — THCA

Explore this box plot interactively →