IGHV7-40

Across TCGA pan-cancer cohorts, IGHV7-40 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of IGHV7-40’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV7-40 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV7-40 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, LUAD, and LIHC are the cancer types where IGHV7-40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV7-40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.596	<.001	8	view →
LUAD	All	All	+0.338	<.001	4	view →
LIHC	All	All	+0.203	.005	2	view →
LUSC	All	All	+0.327	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

IGHV7-40–COAD

Open the COAD breakdown →