IGHV7-40

Across TCGA pan-cancer cohorts, IGHV7-40 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated IGHV7-40 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGHV7-40 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV7-40 expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

UCEC, UCS, and UVM are the cancer types where IGHV7-40 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	III,IV	0.628	0.849	.003	78	view →
UCS	DFS	Tertile	All	0.657	0.168	.001	72	view →
UVM	OS	Tertile	All	0.104	0.834	<.001	63	view →
GBM	OS	Tertile	All	0.064	0.415	<.001	36	view →
ACC	DFS	Tertile	All	0.089	0.666	.010	27	view →
HNSC	DFS	Tertile	III,IV	0.747	0.638	.025	21	view →
LIHC	OS	Tertile	III,IV	0.439	0.673	.017	15	view →
READ	OS	Tertile	IV	1.000	0.629	.039	12	view →
ESCA	OS	Tertile	IV	0.243	0.590	.046	12	view →
SKCM	OS	Median	All	0.410	0.291	.012	11	view →
BRCA	OS	Quartile	IV	1.000	0.604	.015	10	view →
THYM	OS	Tertile	All	0.956	0.610	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

IGHV7-40–UCEC (OS)

Open the UCEC breakdown →