IGHV4-4

Across TCGA patient cohorts, IGHV4-4 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,984 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGHV4-4-associated proteins across cancer lineages are DEF6, MZB1, and CD38. Each is linked with IGHV4-4 in more than 8 cancer types. Because this analysis shows association rather than direction, both IGHV4-4-to-partner and partner-to-IGHV4-4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV4-4 versus DEF6 in GBM, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-4→partner) and Y-score (partner→IGHV4-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DEF6 →	+0.465	+1.033	<.001	<.001	3	9
OV	MZB1 →	+1.077	+2.474	<.001	<.001	3	9
LSCC	CD38 →	+0.745	+1.796	<.001	<.001	3	7
OV	CORO1A →	+0.866	+3.594	<.001	<.001	3	7
OV	GRAP2 →	+0.956	+3.637	.001	.001	3	7
OV	HCLS1 →	+0.786	+3.550	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,984 associations by consensus.

IGHV4-4 vs DEF6 — GBM

Explore this scatter interactively →