IGHV4-31

Across TCGA patient cohorts, IGHV4-31 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,203 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV4-31-associated proteins across cancer lineages are MZB1, HCLS1, and IL16. Each is linked with IGHV4-31 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHV4-31-to-partner and partner-to-IGHV4-31 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV4-31 versus MZB1 in OV, with a Pearson correlation of 0.67.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-31→partner) and Y-score (partner→IGHV4-31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MZB1 →	+1.512	+2.600	<.001	<.001	3	10
GBM	HCLS1 →	+0.479	+0.958	<.001	<.001	3	10
OV	IL16 →	+0.765	+2.934	<.001	<.001	3	10
GBM	LCP1 →	+0.626	+0.890	<.001	<.001	3	10
OV	DOCK2 →	+0.587	+2.224	<.001	<.001	3	10
OV	ARHGAP25 →	+1.032	+3.274	.007	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,203 associations by consensus.

IGHV4-31 vs MZB1 — OV

Explore this scatter interactively →