IGHV4-31

Across TCGA pan-cancer cohorts, IGHV4-31 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of IGHV4-31’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV4-31 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV4-31 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, LUAD, and KIRC are the cancer types where IGHV4-31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV4-31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−2.088	<.001	8	view →
LUAD	All	All	+1.790	<.001	7	view →
KIRC	Male	All	+1.468	<.001	4	view →
READ	All	All	−3.000	.004	2	view →
LIHC	Male	All	−2.100	<.001	2	view →
HNSC	All	III,IV	+1.545	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

IGHV4-31–COAD

Open the COAD breakdown →