IGHV4-31

Across TCGA pan-cancer cohorts, IGHV4-31 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGHV4-31 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV4-31 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV4-31 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where IGHV4-31 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.684	0.520	<.001	144	view →
SKCM	OS	Median	All	0.867	0.682	<.001	63	view →
UVM	DFS	Tertile	All	0.455	0.815	.002	44	view →
UCEC	OS	Tertile	III,IV	0.716	0.369	.002	44	view →
BRCA	OS	Quartile	All	0.974	0.935	.004	28	view →
CHOL	DFS	Median	All	0.662	0.186	.002	27	view →
SARC	OS	Median	All	0.830	0.654	<.001	22	view →
LUAD	DFS	Quartile	III,IV	0.733	0.343	.012	20	view →
ACC	DFS	Median	All	0.775	0.389	.003	17	view →
CESC	DFS	Quartile	All	0.831	0.672	.018	14	view →
MESO	OS	Median	All	0.690	0.327	.019	12	view →
KIRP	OS	Tertile	All	0.607	0.835	.010	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGHV4-31–HNSC (DFS)

Open the HNSC breakdown →