IGHV4-31

Across TCGA patient cohorts, IGHV4-31 protein abundance is significantly associated with the RNA expression of many other genes, with 7,627 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV4-31-associated genes across cancer lineages are IGLV4-69, IGLV6-57, and IGKV1-9. Each is linked with IGHV4-31 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGHV4-31-to-partner and partner-to-IGHV4-31 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV4-31 versus IGLV4-69 in LSCC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-31→partner) and Y-score (partner→IGHV4-31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IGLV4-69 →	+1.890	+0.967	<.001	<.001	3	4
OV	IGLV6-57 →	+2.331	+0.588	.001	.007	3	4
OV	IGKV1-9 →	+2.423	+0.923	.004	.001	3	4
OV	IGHJ3 →	+2.050	+0.874	.005	<.001	3	4
LUAD	LYRM1 →	-0.468	-0.776	<.001	.002	3	3
LSCC	FBXW7 →	+0.315	+0.589	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,627 associations by consensus.

IGHV4-31 vs IGLV4-69 — LSCC

Explore this scatter interactively →