IGHV4-31

Across TCGA patient cohorts, IGHV4-31 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV4-31-associated genes across cancer lineages are RNU6-563P, RNU6-999P, and RNU7-12P. Each is linked with IGHV4-31 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV4-31-to-partner and partner-to-IGHV4-31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-563P grouped by IGHV4-31-low versus IGHV4-31-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-31→partner) and Y-score (partner→IGHV4-31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-563P →	+0.387	+5.792	<.001	.003	3	2
SKCM	RNU6-999P →	+0.250	+4.495	<.001	.007	3	1
SKCM	RNU7-12P →	+0.504	+3.875	<.001	.006	3	1
SKCM	HSPA8P13 →	+0.611	+4.603	<.001	.001	3	1
SKCM	MIR3155A →	+0.635	+3.765	<.001	.007	3	1
SKCM	MIR3117 →	+0.494	+4.796	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

RNU6-563P by IGHV4-31 expression — LUSC

Explore this box plot interactively →