IGHV3OR16-8

Across TCGA patient cohorts, IGHV3OR16-8 protein abundance is significantly associated with the protein abundance of many other proteins, with 788 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGHV3OR16-8-associated proteins across cancer lineages are SAR1B, SDF2L1, and TMED10. Each is linked with IGHV3OR16-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3OR16-8-to-partner and partner-to-IGHV3OR16-8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV3OR16-8 versus SAR1B in LSCC, with a Pearson correlation of 0.68.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3OR16-8→partner) and Y-score (partner→IGHV3OR16-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAR1B →	+0.602	+2.041	.001	<.001	3	1
LSCC	SDF2L1 →	+0.671	+1.944	<.001	.001	3	1
LSCC	TMED10 →	+0.341	+1.291	<.001	<.001	3	1
LSCC	PDIA6 →	+0.543	+1.724	<.001	.003	3	1
BRCA	ACTBL2 →	+0.816	+1.423	<.001	<.001	3	1
BRCA	BTN3A1 →	+0.809	+1.463	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 788 associations by consensus.

IGHV3OR16-8 vs SAR1B — LSCC

Explore this scatter interactively →