IGHV3OR16-17

Across TCGA patient cohorts, IGHV3OR16-17 protein abundance is significantly associated with the RNA expression of many other genes, with 177 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IGHV3OR16-17-associated genes across cancer lineages are ABHD11, CDH23, and MAP3K8. Each is linked with IGHV3OR16-17 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3OR16-17-to-partner and partner-to-IGHV3OR16-17 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IGHV3OR16-17 versus ABHD11 in LUAD, with a Pearson correlation of -0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3OR16-17→partner) and Y-score (partner→IGHV3OR16-17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ABHD11 →	-0.754	-1.345	.005	.004	3	1
LUAD	CDH23 →	+0.552	+1.324	.001	.004	3	1
LUAD	MAP3K8 →	+0.462	+0.990	.005	.004	3	1
LUAD	CYB561D2 →	-0.442	-1.125	.004	.002	3	1
LUAD	HOXD1 →	-1.212	-1.051	.005	.002	3	1
LUAD	CHN1 →	+0.567	+0.969	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 177 associations by consensus.

IGHV3OR16-17 vs ABHD11 — LUAD

Explore this scatter interactively →