IGHV3OR16-17

Across TCGA pan-cancer cohorts, IGHV3OR16-17 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IGHV3OR16-17 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3OR16-17 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3OR16-17 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGHV3OR16-17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.751	0.640	<.001	144	view →
SKCM	OS	Median	II,III,IV	0.409	0.217	<.001	83	view →
BRCA	OS	Tertile	All	0.976	0.936	<.001	50	view →
CHOL	DFS	Median	All	0.721	0.231	.001	48	view →
BLCA	DFS	Median	All	0.700	0.478	.004	32	view →
LGG	OS	Tertile	All	0.190	0.532	<.001	30	view →
COAD	OS	Quartile	IV	0.750	0.078	<.001	23	view →
UVM	OS	Tertile	All	0.316	0.719	.026	18	view →
PAAD	OS	Tertile	II,III,IV	0.658	0.426	.011	11	view →
READ	DFS	Median	IV	0.845	0.356	.001	10	view →
UCEC	OS	Quartile	III,IV	0.748	0.493	.021	10	view →
CESC	DFS	Quartile	All	0.813	0.654	.015	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IGHV3OR16-17–HNSC (DFS)

Open the HNSC breakdown →