IGHV3OR16-17

Across TCGA pan-cancer cohorts, IGHV3OR16-17 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of IGHV3OR16-17’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IGHV3OR16-17 RNA is repressed in tumor relative to normal tissue. In most cancer types IGHV3OR16-17 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

COAD, LUAD, and BRCA are the cancer types where IGHV3OR16-17 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV3OR16-17 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−3.234	<.001	10	view →
LUAD	All	III,IV	+1.803	<.001	8	view →
BRCA	Female	II,III,IV	−0.489	.001	6	view →
KIRC	All	All	+0.416	.001	4	view →
READ	All	All	−2.231	<.001	3	view →
LIHC	Male	III,IV	−0.453	.002	3	view →
STAD	Male	IV	−3.640	.049	1	view →
HNSC	All	III,IV	+0.625	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

IGHV3OR16-17–COAD

Open the COAD breakdown →